A Critical Evaluation of New Localism and Neighbourhood Planning of the UK from a Social and Spatial Equity Perspective: Neighbourhood Planning of Highgate as a Case Study

The devolution of governance to communities is an integral aspect of the state strategy of localism. This paper critically evaluates New Localism and neighbourhood planning from a social and spatial equity aspect, mainly on whether or not this agenda can contribute to fairness especially equal participation, whether people can equally benefit from this agenda and whether the needed spatial housings and amenities are provided. The neighbourhood planning of Highgate will be regarded as a case study

Association of sleep complaints with all-cause and heart disease mortality among US adults

IntroductionCompared with sleep disorders, no consensus has been reached on whether a subjective complaint of having trouble sleeping is associated with increased all-cause and heart disease mortality risk. Previous studies displayed considerable heterogeneity in population disease characteristics and duration of follow-up. Therefore, the aims of this study were to examine the relationship between sleep complaints and all-cause and heart disease mortality and whether the associations were influenced by follow-up time and population disease characteristics. In addition, we aimed to figure out the influence of the joint effects of sleep duration and sleep complaints on mortality risk.MethodsThe present study utilized data from five cycles of the National Health and Nutrition Examination Survey (NHANES) (2005~2014) linked with the most updated 2019 National Death Index (NDI). Sleep complaints were determined by answers to “Have you ever told a doctor or other health professional that you have trouble sleeping?” and “Have you ever been told by a doctor or other health professional that you have a sleep disorder?”. Those who answered ‘Yes' to either of the aforementioned two questions were considered as having sleep complaints.ResultsA total of 27,952 adult participants were included. During a median follow-up of 9.25 years (interquartile range, 6.75–11.75 years), 3,948 deaths occurred and 984 were attributable to heart disease. A multivariable-adjusted Cox model revealed that sleep complaints were significantly associated with all-cause mortality risk (HR, 1.17; 95% CI, 1.07–1.28). Subgroup analysis revealed that sleep complaints were associated with all-cause (HR, 1.17; 95% CI, 1.05–1.32) and heart disease (HR, 1.24; 95% CI, 1.01–1.53) mortality among the subgroup with cardiovascular disease (CVD) or cancer. In addition, sleep complaints were more strongly associated with short-term mortality than long-term mortality. The joint analysis of sleep duration and sleep complaints showed that sleep complaints mainly increased the mortality risk in those with short (< 6 h/day, sleep complaints HR, 1.40; 95% CI, 1.15–1.69) or recommended (6–8 h/day, sleep complaints HR, 1.15; 95% CI, 1.01–1.31) sleep duration group.DiscussionIn conclusion, sleep complaints were associated with increased mortality risk, indicating a potential public benefit of monitoring and managing sleep complaints in addition to sleep disorders. Of note, persons with a history of CVD or cancer may represent a potentially high-risk group that should be targeted with a more aggressive intervention of sleep problems to prevent premature all-cause and heart disease death

BlindHub: Bitcoin-Compatible Privacy-Preserving Payment Channel Hubs Supporting Variable Amounts

Payment Channel Hub (PCH) is a promising solution to the scalability issue of first-generation blockchains or cryptocurrencies such as Bitcoin. It supports off-chain payments between a sender and a receiver through an intermediary (called the tumbler). Relationship anonymity and value privacy are desirable features of privacy-preserving PCHs, which prevent the tumbler from identifying the sender and receiver pairs as well as the payment amounts. To our knowledge, all existing Bitcoin-compatible PCH constructions that guarantee relationship anonymity allow only a (predefined) fixed payment amount. Thus, to achieve payments with different amounts, they would require either multiple PCH systems or running one PCH system multiple times. Neither of these solutions would be deemed practical. In this paper, we propose the first Bitcoin-compatible PCH that achieves relationship anonymity and supports variable amounts for payment. To achieve this, we have several layers of technical constructions, each of which could be of independent interest to the community. First, we propose $\textit{BlindChannel}$, a novel bi-directional payment channel protocol for privacy-preserving payments, where {one of the channel parties} is unable to see the channel balances. Then, we further propose $\textit{BlindHub}$, a three-party (sender, tumbler, receiver) protocol for private conditional payments, where the tumbler pays to the receiver only if the sender pays to the tumbler. The appealing additional feature of BlindHub is that the tumbler cannot link the sender and the receiver while supporting a variable payment amount. To construct BlindHub, we also introduce two new cryptographic primitives as building blocks, namely $\textit{Blind Adaptor Signature}$(BAS), and $\textit{Flexible Blind Conditional Signature}$. BAS is an adaptor signature protocol built on top of a blind signature scheme. Flexible Blind Conditional Signature is a new cryptographic notion enabling us to provide an atomic and privacy-preserving PCH. Lastly, we instantiate both BlindChannel and BlindHub protocols and present implementation results to show their practicality

Primary Effusion Lymphoma: A Clinicopathological Study of 70 Cases

Primary effusion lymphoma (PEL) is a rare type of large B-cell lymphoma associated with human herpesvirus 8 (HHV8) infection. Patients with PEL usually present with an effusion, but occasionally with an extracavitary mass. In this study, we reported a cohort of 70 patients with PEL: 67 men and 3 women with a median age of 46 years (range 26-91). Of these, 56 (80%) patients had human immunodeficiency virus (HIV) infection, eight were HIV-negative, and six had unknown HIV status. Nineteen (27%) patients had Kaposi sarcoma. Thirty-five (50%) patients presented with effusion only, 27 (39%) had an extracavitary mass or masses only, and eight (11%) had both effusion and extracavitary disease. The lymphoma cells showed plasmablastic, immunoblastic, or anaplastic morphology. All 70 (100%) cases were positive for HHV8. Compared with effusion-only PEL, patients with extracavitary-only PEL were younger (median age, 42 vs. 52 years, p = 0.001), more likely to be HIV-positive (88.9% vs. 68.6%, p = 0.06) and EBV-positive (76.9% vs. 51.9%, p = 0.06), and less often positive for CD45 (69.2% vs. 96.2%, p = 0.01), EMA (26.7% vs. 100%, p = 0.0005), and CD30 (60% vs. 81.5%, p = 0.09). Of 52 (50%) patients with clinical follow-up, 26 died after a median follow-up time of 40.0 months (range 0-96), and the median overall survival was 42.5 months. The median OS for patients with effusion-only and with extracavitary-only PEL were 30.0 and 37.9 months, respectively (p = 0.34), and patients with extracavitary-only PEL had a lower mortality rate at the time of last follow-up (35% vs. 61.5%, p = 0.07). The median OS for HIV-positive and HIV-negative patients were 42.5 and 6.8 months, respectively (p = 0.57), and they had a similar mortality rate of 50% at last follow-up. In conclusion, patients presenting with effusion-only versus extracavitary-only disease are associated with different clinicopathologic features. PEL is an aggressive lymphoma with a poor prognosis, regardless of extracavitary presentation or HIV status

Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

Funder: NCI U24CA211006Abstract: The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and WGS side-by-side from 746 TCGA samples, finding that ~80% of mutations overlap in covered exonic regions. We estimate that low variant allele fraction (VAF < 15%) and clonal heterogeneity contribute up to 68% of private WGS mutations and 71% of private WES mutations. We observe that ~30% of private WGS mutations trace to mutations identified by a single variant caller in WES consensus efforts. WGS captures both ~50% more variation in exonic regions and un-observed mutations in loci with variable GC-content. Together, our analysis highlights technological divergences between two reproducible somatic variant detection efforts

阿里巴巴和京东：战略、商业模式与财务报表

中国电商行业经过十几年的发展，培育出阿里巴巴和京东两大巨头：一个是最大的平台电商，一个是最大的自营电商。2014年，阿里巴巴和京东相继上市，2015年上半年又相继披露了上市后的首份财报。这两份财报很快就吸引了张伟这位刚从EMBA毕业的投资助理的注意，他开始思索，作为中国电商行业的领头羊，阿里巴巴和京东在战略和商业模式方面到底有什么区别，这些区别会影响它们的财务报表吗？这两家公司有什么投资亮点呢